The vertebrate segmentation clock
نویسندگان
چکیده
منابع مشابه
Building the spine: the vertebrate segmentation clock.
One of the most striking characteristics of many animal and plant species is their organization in a series of periodically repeated anatomical modules. In animals, this particular patterning strategy of the body axis is termed segmentation, and it is observed in both vertebrates and invertebrates. Vertebrate segmentation has been associated with a molecular oscillator-the segmentation clock-wh...
متن کاملVertebrate segmentation: The clock is linked to Notch signalling
The periodic formation of somites during vertebrate segmentation has been suggested to involve a molecular 'segmentation clock'. Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos link the segmentation clock to Delta-Notch signalling.
متن کاملTiming Embryo Segmentation: Dynamics and Regulatory Mechanisms of the Vertebrate Segmentation Clock
All vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, t...
متن کاملNotch signaling, the segmentation clock, and the patterning of vertebrate somites
The Notch signaling pathway has multifarious functions in the organization of the developing vertebrate embryo. One of its most fundamental roles is in the emergence of the regular pattern of somites that will give rise to the musculoskeletal structures of the trunk. The parts it plays in the early operation of the segmentation clock and the later definition and differentiation of the somites a...
متن کاملPatterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock.
The segmentation clock is an oscillating genetic network thought to govern the rhythmic and sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the precursors of the segmented vertebral column. Understanding how the rhythmic signal arises, how it achieves precision and how it patterns the embryo remain challenging issues. Recent work has provided evidence o...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2001
ISSN: 0021-8782,1469-7580
DOI: 10.1017/s0021878201008214